What is the PRENALTEROL?

PRENALTEROL is , while it's Molecular Formula is C12H19 N O3. Prenalterol is a ß1-adrenergic agonist and used as an cardiotonic (1,2,3).

What is the CAS number for PRENALTEROL?

The CAS number of PRENALTEROL is 57526-81-5.

What is PRENALTEROL (57526-81-5) used for?

Prenalterol, a ß1-adrenergic agonist, is a pharmaceutical compound that plays a significant role in the treatment of various cardiovascular conditions. It works by stimulating the ß1-adrenergic receptors, which are predominantly found in the heart, leading to an increase in heart contractility and rate. This action makes Prenalterol a valuable asset in managing heart-related issues.InChI:InChI=1/C12H19NO3/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12/h3-6,9,11,13-15H,7-8H2,1-2H3

What is the PRENALTEROL?

PRENALTEROL is , while it's Molecular Formula is C12H19 N O3. Prenalterol is a β1-adrenergic agonist and used as an cardiotonic (1,2,3).

What is the CAS number for PRENALTEROL?

The CAS number of PRENALTEROL is 57526-81-5.

What is PRENALTEROL (57526-81-5) used for?

Prenalterol, a β1-adrenergic agonist, is a pharmaceutical compound that plays a significant role in the treatment of various cardiovascular conditions. It works by stimulating the β1-adrenergic receptors, which are predominantly found in the heart, leading to an increase in heart contractility and rate. This action makes Prenalterol a valuable asset in managing heart-related issues.InChI:InChI=1/C12H19NO3/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12/h3-6,9,11,13-15H,7-8H2,1-2H3

High Quality Chinese Manufacturer supply 57526-81-5 PRENALTEROL

PRENALTEROL

CAS No.:57526-81-5
Purity:99%

High Quality Chinese Manufacturer supply 57526-81-5 PRENALTEROL

Molecular Formula:C12H19 N O3
Molecular Weight:225.288
Vapor Pressure:4.86E-07mmHg at 25°C
Melting Point:127-128°
Boiling Point:397.7°Cat760mmHg
PKA:pKa 9.5 (Uncertain);10.0 (Uncertain)
Flash Point:194.3°C
PSA：61.72000
Density:1.118g/cm³
LogP:1.52080

PRENALTEROL(Cas 57526-81-5) Usage

InChI:InChI=1/C12H19NO3/c1-9(2)13-7-11(15)8-16-12-5-3-10(14)4-6-12/h3-6,9,11,13-15H,7-8H2,1-2H3

57526-81-5 Relevant articles

Effective synthesis of non-racemic prenalterol based on spontaneous resolution of 3-(4-hydroxyphenoxy)propane-1,2-diol

Bredikhina, Zemfira A.,Kurenkov, Alexey V.,Bredikhin, Alexander A.

, p. 198 - 199 (2019/04/25)

Spontaneous resolution of rac-3-(4-hydro...

METHODS FOR DIAGNOSING, MONITORING AND TREATING NEUROLOGICAL DISEASES AND DISORDERS

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Paragraph 0104, (2020/01/08)

In various aspects and embodiments provi...

Synthesis of (S)-β-Blockers from (S)-5-Hydroxymethyl-3-tert butyl-2-oxazolidinone or (S)-5-Hydroxymethyl-3-isopropyl-2-oxazolidinone

Kan, Kazunori,Miyama, Akimasa,Hamaguchi, Shigeki,Ohashi, Takehisa,Watanabe, Kiyoshi

, p. 207 - 210 (2007/10/02)

Substituted (10H-phenothiazin-10-L)-propyl-1-piperazines

-

, (2008/06/13)

Substituted (10H-phenothiazin-10-yl)prop...

57526-81-5 Process route

: 57526-82-6
(2S)-1-<4-(benzyloxy)phenoxy>-3-<(1-methylethyl)amino>-2-propanol

: 57526-81-5
prenalterol

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; In methanol; for 0.666667h; under 760 Torr; Ambient temperature;	92.3%

: 86955-00-2
(S)-N-isopropyl-2,3-O-isopropylidene-D-glyceraldimine

: 57526-81-5
prenalterol

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1: H₂ / 10percent Pd/C / 760 Torr / Ambient temperature 2: 95 percent / triethylamine / CH₂Cl₂ / 0.5 h / 10 - 15 °C 3: 84.6 percent / Dowex₅₀W-8x ion-exchange resin (H⁺ form / aq. ethanol / 1.5 h / Heating 4: 264 g / benzoic acid / 0.5 h 5: 268 g / trimethylchlorosilane / CH₂Cl₂ / 0.75 h / Heating 6: 182 g / aq. NaOH / methanol / 0.5 h / 15 °C 7: 92 percent / Na, MeOH / 16 h / Heating 8: POCl₃ / toluene / 1.5 h / Ambient temperature 9: sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 1.5 h / 80 °C 10: 92.3 percent / H₂ / 10percent Pd/C / methanol / 0.67 h / 760 Torr / Ambient temperature With methanol; sodium hydroxide; chloro-trimethyl-silane; Dowex₅₀W-8x ion-exchange resin (H⁺ form; hydrogen; sodium; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; benzoic acid; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; toluene;

Yield

Multi-step reaction with 10 steps

1: H₂ / 10percent Pd/C / 760 Torr / Ambient temperature

2: 95 percent / triethylamine / CH₂Cl₂ / 0.5 h / 10 - 15 °C

3: 84.6 percent / Dowex₅₀W-8x ion-exchange resin (H⁺ form / aq. ethanol / 1.5 h / Heating

4: 264 g / benzoic acid / 0.5 h

5: 268 g / trimethylchlorosilane / CH₂Cl₂ / 0.75 h / Heating

6: 182 g / aq. NaOH / methanol / 0.5 h / 15 °C

7: 92 percent / Na, MeOH / 16 h / Heating

8: POCl₃ / toluene / 1.5 h / Ambient temperature

9: sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 1.5 h / 80 °C

10: 92.3 percent / H₂ / 10percent Pd/C / methanol / 0.67 h / 760 Torr / Ambient temperature

With methanol; sodium hydroxide; chloro-trimethyl-silane; Dowex₅₀W-8x ion-exchange resin (H⁺ form; hydrogen; sodium; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; benzoic acid; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol; dichloromethane; toluene;

57526-81-5 Upstream products

57526-82-6
(2S)-1-<4-(benzyloxy)phenoxy>-3-<(1-methylethyl)amino>-2-propanol
103-16-2
4-Benzyloxyphenol
68430-29-5
(S)-5-hydroxymethyl-3-(methylethyl)oxazolidinone
68430-35-3
(S)-3-isopropyl-5-p-toluenesulfonyloxymethyl-oxazolidin-2-one

57526-81-5 Downstream products

86955-34-2
(S)-1-(4-{8-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-octyloxy}-phenoxy)-3-isopropylamino-propan-2-ol
86955-37-5
(S)-1-(4-{12-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-dodecyloxy}-phenoxy)-3-isopropylamino-propan-2-ol
86955-39-7
(S)-1-(4-{14-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-tetradecyloxy}-phenoxy)-3-isopropylamino-propan-2-ol
86955-41-1
(S)-1-(4-{20-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-icosyloxy}-phenoxy)-3-isopropylamino-propan-2-ol